RT Journal Article
T1 Ideal cardiovascular health in women with systemic lupus erythematosus: Association with arterial stiffness, inflammation, and fitness
A1 Hernández-Martínez, Alba
A1 Gavilán-Carrera, Blanca
A1 Vargas-Hitos, José A
A1 Morillas-de-Laguno, Pablo
A1 Sola-Rodríguez, Sergio
A1 Rosales-Castillo, Antonio
A1 Artero, Enrique
A1 Sabio, José M
A1 Soriano-Maldonado, Alberto
K1 Lupus eritematoso
AB MethodsThis cross-sectional study included 76 women with SLE (age 43.4±13.8 years old). Ideal levels of 7 health metrics (smoking, body mass index, physical activity, healthy diet, blood pressure, cholesterol, and glucose) were used to define the ICH score (ranging from 0 to 7 ideal metrics) and the ICH status ( defined as presenting ≥4 ideal metrics). Arterial stiffness was measured through pulse wave velocity (PWV) and inflammation through serum high sensitivity C-reactive protein (hs-CRP). Cardiorespiratory fitness (CRF) was measured by 6-min walk test (6MWT), and Siconolfi step test and muscular strength by handgrip strength and 30-s chair stand, and range of motion (ROM) by the back-scratch test.ResultsHigher ICH score was associated with lower PWV (β = −0.122, p = 0.002), lower hs-CRP (β = −0.234, p = 0.056), higher CRF [6MWT (β = 0.263, p = 0.041); Siconolfi step test (β = 0.330, p < 0.001)], higher ROM (β = 0.278, p = 0.013) and higher relative handgrip strength (β = 0.248, p = 0.024). Women with ICH status presented lower PWV (mean difference 0.40 m/s, 95% CI 0.17 to 0.63, p = 0.001), and higher CRF [assessed by 6MWT (mean difference 43.9 m, 95% CI 5.0 to 82.7, p = 0.028)], than women with non-ICH status. Sensitivity analyses using ICH score ranging 0–14 and considering ICH status with ≥5 metrics revealed consistent results.ConclusionICH is associated with lower arterial stiffness, lower inflammation, and higher fitness in women with SLE. Although these results extend current knowledge about the potential role of ICH for primordial prevention of CVD in SLE, they are yet to be confirmed in future prospective research
PB Elsevier
YR 2021
FD 2021-05
LK https://hdl.handle.net/10630/37614
UL https://hdl.handle.net/10630/37614
LA eng
NO Hernández-Martínez, Alba et al. Ideal cardiovascular health in women with systemic lupus erythematosus: Association with arterial stiffness, inflammation, and fitness.International Journal of Cardiology, Volume 330, 207 - 213
NO Thisworkwas funded by the Consejería de Salud, Junta de Andalucía (grant numbers: PI-0525-2016 and PIER-0223-2019). AHM was supported by Plan Propio, ""Gerty Cori progra"" from University of Almería, Spain. BGCwas supported by the SpanishMinistry of Education (FPU15/00002).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 13 abr 2026