RT Journal Article
T1 Effect of a Triterpenoid-Rich Olive Oil on Chronic Kidney Disease in an Experimental Model of Diabetes Mellitus
A1 De-la-Cruz-Cortés, José Pedro
A1 Osuna-Esteban, Laura
A1 Rodríguez-Pérez, María Dolores
A1 Ortega-Hombrados, Laura
A1 Sánchez Tévar, Ana María
A1 Martín Aurioles, Esther
A1 Fernández-Prior, María África
A1 Pérez-Burillo, Sergio
A1 Espejo-Calvo, Juan Antonio
A1 González-Correa, José Antonio
K1 Nefropatías diabéticas
AB The aim of this study was to assess the effect of triterpenoids on the development of diabetic nephropathy in an experimental model of diabetes mellitus. For this purpose, a destoned and dehydrated olive oil (DDOO) was used, comparing its effects to a destoned olive oil (DOO). DDOO had a higher triterpenoid content than DOO but an equal content of alcoholic polyphenols. Four study groups (n = 10 animals/group) were formed: healthy rats, diabetic control rats (DRs), and DRs treated orally with 0.5 mL/kg/day of DOO or DDOO for two months. DRs showed impaired renal function (proteinuria, increased serum creatinine, decreased renal creatinine clearance) and morphology (glomerular volume and glomerulosclerosis). These alterations correlated with increased systemic and renal tissue oxidative stress and decreased prostacyclin production. DDOO administration significantly reduced all variables of renal damage, as well as systemic and renal oxidative stress, to a greater extent than the effect produced by DOO. In conclusion, triterpenoid-rich olive oil may prevent kidney damage in experimental diabetes mellitus
PB MDPI
YR 2024
FD 2024-08-21
LK https://hdl.handle.net/10630/38633
UL https://hdl.handle.net/10630/38633
LA eng
NO De La Cruz JP, Osuna-Esteban L, Rodríguez-Pérez MD, Ortega-Hombrados L, Sánchez-Tévar AM, Martín-Aurioles E, et al. Effect of a Triterpenoid-Rich Olive Oil on Chronic Kidney Disease in an Experimental Model of Diabetes Mellitus. Nutrients 2024, Vol 16, Page 2794. 2024;16:2794.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 27 feb 2026