RT Journal Article
T1 Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine
A1 Mañas-Padilla, María del Carmen
A1 Ávila-Gámiz, Fabiola
A1 Gil-Rodríguez, Sara
A1 Ladrón de Guevara-Miranda, David
A1 Rodriguez-de-Fonseca, Fernando
A1 Santín-Núñez, Luis Javier
A1 Castilla-Ortega, María Estela
K1 Ansiedad
AB Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animalmodels. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses arescarcely reported. In this study, mice were administered with cocaine (20 mg/kg/day) or vehicle for 12consecutive days. After 24 days of drug abstinence, a behavioral assessment was carried out in drug-free conditionsand in unfamiliar environments (i.e. no cocaine-associated cues were presented). The cocaine-withdrawnmice showed cognitive deficits in spontaneous alternation behavior and place recognition memory. Importantly,they also displayed hyperlocomotion, increased rearing activity and altered exploratory patterns in differenttasks. In the forced swimming test, they were more active (struggled/climbed more) when trying to escape fromthe water albeit showing normal immobility behavior. In conclusion, in addition to cognitive deficits, chroniccocaine in rodents may induce long-lasting alterations in exploratory activity and psychomotor activation thatare triggered even in absence of drug-related stimuli.
PB Elsevier
YR 2021
FD 2021
LK https://hdl.handle.net/10630/22747
UL https://hdl.handle.net/10630/22747
LA eng
NO This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (MINECO, Agencia Estatal de Investigación –AEI-) cofounded by the European Regional Development Fund-FEDER, UE- (PSI2015–73,156-JIN to E.C–O.; PSI2017–82604R to L.J.S.), RETICS Red de Trastornos Adictivos (ERDF-EU; RD16/0017/0001 to F.R.F.) and University of Málaga (B4: ‘Ayudas para Proyectos Puente’to E.C–O). Funding for open access charge: Universidad de Málaga /CBUA.Authors M.C.M-P., F. A-G. and S. G-R. hold predoctoral grants from the Spanish Ministry of Science, Innovation and Universities (FPU17/00276 to M.C.M-P.; PRE2018–085673 to F.A-G.; and FPU18/00941 to S.G-R.). Author D.L.G.M. holds a postdoctoral grant from University of Málaga (A.3. Plan Propio de Investigación y Transferencia Universidad de Málaga).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026