RT Journal Article
T1 Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet
A1 Mela-Rivas, Virginia
A1 Piscitelli, Fabiana
A1 Llorente-Berzal, Álvaro
A1 Chowen, Julie Ann
A1 Silvestri, Christoforo
A1 Viveros, María Paz
A1 Di Marzo, Vincenzo
K1 Tejido adiposo
K1 Cannabinoides
K1 Lípidos en nutrición
K1 Acidos grasos
AB Maternal deprivation (MD) during neonatal life has diverse long-term effects,including modification of metabolism. We have previously reported that MD modifies themetabolic response to high-fat diet (HFD) intake, with this response being differentbetween males and females, while previous studies indicate that in mice with HFDinduced obesity, endocannabinoid (EC) levels are markedly altered in various brown andwhite adipose tissue depots. Here, we analyzed the effects of MD (24 h at postnatal day9), alone or in combination with a HFD from weaning until the end of the experiment inWistar rats of both sexes. Brown and white perirenal and subcutaneous adipose tissueswere collected and the levels of anandamide (AEA), 2- arachidonoylglycerol (2-AG),palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) were determined. Inmales, MD increased the content of OEA in brown and 2-AG in subcutaneous adiposetissues, while in females the content of 2-AG was increased in perirenal fat. Moreover, infemales, MD decreased AEA and OEA levels in perirenal and subcutaneous adipose tissues, respectively. HFD decreased the content of 2-AG in brown fat of both sexes andOEA in brown and subcutaneous adipose tissue of control females. In contrast, insubcutaneous fat, HFD increased AEA levels in MD males and OEA levels in control andMD males. The present results show for the first time that MD and HFD induce sexdependent effects on the main ECs, AEA, and 2-AG, and of AEA-related mediators, OEAand PEA, in the rat brown and white (visceral and subcutaneous) adipose tissues.
PB Springer
YR 2016
FD 2016-08
LK https://hdl.handle.net/10630/40715
UL https://hdl.handle.net/10630/40715
LA eng
NO Mela V, Piscitelli F, Berzal AL, Chowen J, Silvestri C, Viveros MP, Di Marzo V. Sex-dependent effects of neonatal maternal deprivation on endocannabinoid levels in the adipose tissue: influence of diet. J Physiol Biochem. 2016 Aug;73(3):349-357. doi: 10.1007/s13105-017-0558-0. Epub 2017 Mar 23. Erratum in: J Physiol Biochem. 2017 Nov;73(4):623. doi: 10.1007/s13105-017-0593-x. PMID: 28337718.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026