RT Journal Article
T1 Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
A1 Molina, Noemí
A1 González, Ana
A1 Monopoli, Donato
A1 Mentado, Belinda
A1 Becerra-Ratia, José
A1 Santos-Ruiz, Leonor
A1 Vida-Pol, Yolanda
A1 Pérez-Inestrosa, Ezequiel
K1 Implantes artificiales
K1 Células dendríticas
K1 Implantes dentales
K1 Titanio
K1 Huesos
AB Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.
PB MDPI
SN 2073-4360
YR 2020
FD 2020-04-01
LK https://hdl.handle.net/10630/30520
UL https://hdl.handle.net/10630/30520
LA eng
NO Molina, N.; González, A.; Monopoli, D.; Mentado, B.; Becerra, J.; Santos-Ruiz, L.; Vida, Y.; Perez-Inestrosa, E. Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility. Polymers 2020, 12, 770.
NO Ministerio de Economía y Competitividad - MINECO (BIO2015-66266-R)Ministerio de Economía y Competitividad - MINECO (CTQ2016-75870-P)Ministerio de Educación, Formación Profesional y Deportes - MECD (FPU15/00641)Junta de Andalucía (PI0250-2016)Junta de Andalucía (PI-0555-2013)Junta de Andalucía (UMA-FEDERJA-007)Junta de Andalucía (PAIDI-FQM-017)Junta de Andalucía (PAIDI-BIO-217)10% Partial funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026