RT Journal Article
T1 Mechanosensitive PIEZO2 channels shape coronary artery 28 development
A1 Pampols-Perez, Mireia
A1 Fürst, Carina
A1 Sánchez-Carranza, Oscar
A1 Cano, Elena
A1 García-Contreras, Jonathan Alexis
A1 Mais, Lisa
A1 Luo, Wenhan
A1 Raimundo, Sandra
A1 Lindberg, Eric L.
A1 Taube, Martin
A1 Heuser, Arnd
A1 Sporbert, Anje
A1 Kainmueller, Dagmar
A1 Bernabeu, Miguel O.
A1 Hübner, Norbert
A1 Gerhardt, Holger
A1 Lewin, Gary R.
A1 Hammes, Annette
K1 Arterias coronarias
K1 Circulación coronaria
K1 Corazón - Enfermedades
AB Coronary arteries develop under constant mechanical stress. However, the role of mechanosensitive ion channels in this process remains poorly understood. Here we show that the ion channel PIEZO2, which responds to mechanical stimuli, is expressed in specific coronary endothelial cell populations during a critical phase of coronary vasculature remodeling. These Piezo2+ coronary endothelial cells show distinct transcriptional profiles and have mechanically activated ionic currents. Strikingly, PIEZO2 loss-of-function mouse embryos and mice with human pathogenic variants of PIEZO2 show abnormal coronary vessel development and cardiac left ventricular hyperplasia. We conclude that an optimal balance of PIEZO2 channel function contributes to proper coronary vessel formation, structural integrity and remodeling, and is likely to support normal cardiac function. Our study highlights the importance of mechanical cues in cardiovascular development and suggests that defects in this mechanosensing pathway may contribute to congenital heart conditions.
PB Springer Nature
YR 2025
FD 2025-06-27
LK https://hdl.handle.net/10630/39366
UL https://hdl.handle.net/10630/39366
LA eng
NO Pampols-Perez, M., Fürst, C., Sánchez-Carranza, O. et al. Mechanosensitive PIEZO2 channels shape coronary artery development. Nat Cardiovasc Res 4, 921–937 (2025). https://doi.org/10.1038/s44161-025-00677-3
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026