RT Conference Proceedings
T1 Galanin (1-15) enhances the behavioural effects of escitalopram in the forced swimming test in rats
A1 García-Durán, Laura
A1 Cantero-García, Noelia
A1 Flores-Burgess, Antonio
A1 Gago-Calderón, Belén
A1 Puigcerver-Martínez, Araceli
A1 Narváez-Bueno, José Ángel
A1 Santín-Núñez, Luis Javier
A1 Millón-Peñuela, Carmelo
A1 Díaz-Cabiale, Zaida
K1 Biomedicina -- Investigación
AB The selective serotonergic reuptake inhibitors (SSRIs) are the most commonly used for thetreatment of major depression. Recently, we observed that the Galanin N-terminal fragment(1-15) [GAL(1-15)] enhances the antidepressant-like effects induced by Fluoxetine(FLX) in the forced swimming test (FST) (Flores-Burgess et al, 2017). Therefore, we haveanalyzed the ability of GAL(1-15) to enhance the behavioural effects of Escitalopram(ESC), other SSRIs, in the FST and the tail suspension test (TST).In the first set of experiments, groups of rats received three injections (23, 5 and 1 hour)before FST of two different doses of ESC (5mg/Kg or 7,5mg/Kg) or vehicle to perform adose-response curve in the FST. Secondly, different groups of rats received three injectionsof ESC (7,5mg/Kg) and a single injection of a threshold dose of GAL(1-15) (1nmol) oraCSF 15 minutes before the FST and TST.In the dose-response curve, ESC 5 mg/kg and 7,5 mg/kg significantly increase the swimmingtime (p<0.05), while lacking effects over immobility time. The threshold dose ofGAL(1-15) 1nmol enhanced the antidepressant-like effects mediated by ESC 7,5mg/Kg,decreasing the immobility (p<0.05) and increasing the swimming time (p<0.05) in the FST.In TST, no differences were found between the treatments.Our results indicate an interaction between GAL(1-15) and ESC in the FST and open upthe possibility to use GAL(1-15) for a combination therapy with SSRIs as a depressiontreatment.
YR 2021
FD 2021-01-22
LK https://hdl.handle.net/10630/20828
UL https://hdl.handle.net/10630/20828
LA eng
NO This study was supported by Spanish SAF2016-79008-P, PI-0083-2019 and UMA18-FEDERJA-008Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026