RT Journal Article
T1 Hepatic safety of atypical antipsychotics: current evidence and future directions
A1 Slim, Mahmoud
A1 Medina-Cáliz, Inmaculada
A1 González-Jiménez, Andrés
A1 Cabello-Porras, María Rosario
A1 Mayoral Cleries, Fermín
A1 Lucena-González, María Isabel
A1 Andrade-Bellido, Raúl Jesús
K1 Hígado -  Efectos de los medicamentos
AB The newer atypical antipsychotic agents (AAPs) represent an attractive therapeutic option for a wide range of psychotic disorders, including schizophrenia and bipolar mania, because of the reduced risk of disabling extrapyramidal symptoms. However, their growing use has raised questions about their tolerability over the endocrine, metabolic, and cardiovascular axes. Indeed, atypical antipsychotic drugs are associated, to differing extents, with mild elevation of aminotransferases related to weight gain, AAP-induced metabolic syndrome, and nonalcoholic fatty liver disease. Although the hepatic safety of new AAPs seems improved over that of chlorpromazine, they can occasionally cause idiosyncratic liver injury with varying phenotypes and, rarely, lead to acute liver failure. However, AAPs are a group of heterogeneous, chemically unrelated compounds with distinct pharmacological and pharmacokinetic properties and substantially different safety profiles, which precludes the notion of a class effect for hepatotoxicity risk and highlights the need for an individualized therapeutic approach. We discuss the current evidence on the hepatotoxicity potential of AAPs, the emerging underlying mechanisms, and the limitations inherent to this group of drugs for both establishing a proper causality assessment and developing strategies for risk management.
PB Springer, ADIS INT LTD
YR 2016
FD 2016-10
LK https://hdl.handle.net/10630/29759
UL https://hdl.handle.net/10630/29759
LA eng
NO Slim, M., Medina-Caliz, I., Gonzalez-Jimenez, A. et al. Hepatic Safety of Atypical Antipsychotics: Current Evidence and Future Directions. Drug Saf 39, 925–943 (2016). https://doi.org/10.1007/s40264-016-0436-7
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 27 feb 2026