RT Journal Article
T1 Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome
A1 Matas-Rico, Elisa
A1 van Veen, Wouter H
A1 Leyton-Puig, Daniela
A1 van den Berg, Jeroen
A1 Koster, Jan
A1 Kedziora, Katarzyna M
A1 Molenaar, Bas
A1 J A Weerts, Marjolein
A1 de Rink, Iris
A1 Medema, René H
A1 Giepmans, Ben N G
A1 Perrakis, Anastassis
A1 Jalink, Kees
A1 Versteeg, Rogier
A1 van Veen, 
K1 Neuroblastoma
AB Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation.A better understanding of neuroblastoma differentiation is essential for developing new therapeuticapproaches. GDE2 (encoded by GDPD5) is a six-transmembrane-domain glycerophosphodiesterasethat promotes embryonic neurogenesis. We find that high GDPD5 expression is strongly associatedwith favorable outcome in neuroblastoma. GDE2 induces differentiation of neuroblastoma cells, suppresses cell motility, and opposes RhoA-driven neurite retraction. GDE2 alters the Rac-RhoA activitybalance and the expression of multiple differentiation-associated genes. Mechanistically, GDE2 actsby cleaving (in cis) and releasing glycosylphosphatidylinositol-anchored glypican-6, a putative co-receptor. A single point mutation in the ectodomain abolishes GDE2 function. Our results reveal GDE2as a cell-autonomous inducer of neuroblastoma differentiation with prognostic significance and potential therapeutic value.
PB Elsevier
YR 2016
FD 2016-10
LK https://hdl.handle.net/10630/34419
UL https://hdl.handle.net/10630/34419
LA eng
NO Elisa Matas-Rico, Michiel van Veen, Daniela Leyton-Puig, Jeroen van den Berg, Jan Koster, Katarzyna M. Kedziora, Bas Molenaar, Marjolein J.A. Weerts, Iris de Rink, René H. Medema, Ben N.G. Giepmans, Anastassis Perrakis, Kees Jalink, Rogier Versteeg, Wouter H. Moolenaar, Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome, Cancer Cell, Volume 30, Issue 4, 2016, Pages 548-562, ISSN 1535-6108, https://doi.org/10.1016/j.ccell.2016.08.016.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026