RT Journal Article
T1 LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
A1 Cobo-Vuilleumier, Nadia
A1 Lorenzo, Petra I
A1 García Rodríguez, Noelia
A1 Herrera Gómez, Irene de Gracia
A1 Fuente-Martin, Esther
A1 López-Noriega, Livia
A1 Mellado-Gil, José Manuel
A1 Romero-Zerbo, Silvana Yanina
A1 Baquié, Mathurin
A1 Lachaud, Christian Claude
A1 Stifter, Katja
A1 Perdomo, German
A1 Bugliani, Marco
A1 De Tata, Vincenzo
A1 Bosco, Domenico
A1 Parnaud, Geraldine
A1 Pozo, David
A1 Hmadcha, Abdelkrim
A1 Florido, Javier P
A1 Toscano, Miguel G
A1 de Haan, Peter
A1 Schoonjans, Kristina
A1 Sánchez Palazón, Luis
A1 Marchetti, Piero
A1 Schirmbeck, Reinhold
A1 Martín-Montalvo, Alejandro
A1 Meda, Paolo
A1 Bernat, Soria
A1 Bermúdez Silva, Francisco Javier
A1 St-Onge, Luc
A1 Gauthier, Benoit R
A2 Hmadcha, Abdelkrim
K1 Diabetes
AB Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells byimmune cells. Current therapies focused on repressing the immune attack or stimulating betacell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovativetargets to dampen the immune process, while promoting beta cell survival and function. Liverreceptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestiveorgans, and protects pancreatic islets against apoptosis. Here, we show that BL001, a smallLRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammationof pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabeticpatients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1agonism favors a dialogue between immune and islet cells, which could be druggable toprotect against diabetes mellitus.
PB Nature Research
YR 2018
FD 2018
LK https://hdl.handle.net/10630/32312
UL https://hdl.handle.net/10630/32312
LA eng
NO Cobo-Vuilleumier, N., Lorenzo, P.I., Rodríguez, N.G. et al. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nat Commun 9, 1488 (2018). https://doi.org/10.1038/s41467-018-03943-0
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026