RT Journal Article
T1 The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis.
A1 Pinto-Medel, María Jesús
A1 García-León, Juan Antonio
A1 Oliver-Martos, Begoña
A1 López-Gómez, Carlos
A1 Luque, Gloria
A1 Arnáiz-Urrutia, Carlos
A1 Órpez, Teresa
A1 Marín-Bañasco, Carmen
A1 Fernández Fernández, Óscar
A1 Leyva-Fernández, Laura
K1 Esclerosis múltiple
K1 Moleculas de adhesión celular
K1 Células T
AB Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells areconsidered to play a pivotal role.CD28 is the quintessential costimulatory molecule on T-cells and its expressiondeclines progressively with repeated stimulations, leading to the generation ofCD28− T-cells. Our aim was to examine whether CD4+CD28- T cells wereenriched in MS patients, and characterize the phenotype of this subset in MSpatients and healthy controls (HC).All these changes could provide these CD4+CD28- T cell characteristics thatmight be involved in the pathogenesis of MS, turning this T-cell subset into apotential target for future therapeutic strategies.
PB Elsevier
YR 2012
FD 2012-01-18
LK https://hdl.handle.net/10630/34400
UL https://hdl.handle.net/10630/34400
LA eng
NO Pinto-Medel MJ, García-León JA, Oliver-Martos B, López-Gómez C, Luque G, Arnáiz-Urrutia C, Orpez T, Marín-Bañasco C, Fernández O, Leyva L. The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis. J Neuroimmunol. 2012 Feb 29;243(1-2):1-11
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026