RT Journal Article
T1 Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
A1 Cueto-Sánchez, Alejandro
A1 Niu, Hao
A1 Álvarez-Álvarez, Ismael
A1 López-Longarela, Bárbara
A1 Del Campo-Herrera, Enrique
A1 Ortega-Alonso, Aida
A1 García-Cortés, Miren
A1 Pinazo-Bandera, José M.
A1 Sanabria-Cabrera, Judith Adriana
A1 Díaz-Monchón, Juan José
A1 Lucena-González, María Isabel
A1 Andrade-Bellido, Raúl Jesús
A1 Stephens, Camilla
A1 Robles-Díaz, María Mercedes
K1 Hígado - Enfermedades - Quimioterapia -Complicaciones y secuelas - Diagnóstico
K1 Medicamentos - Efectos secundarios
K1 Medicamentos - Toxicología
AB AimsDetection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis can be delayed, with important consequences for the patient. In this study, we aimed to evaluate the potential of osteopontin, cytokeratin-18 (caspase-cleaved: ccK18 and total: K18), α-glutathione-S-transferase and microRNA-122 as new DILI biomarkers.MethodsSerial blood samples were collected from 32 DILI and 34 non-DILI acute liver injury (ALI) cases and a single sample from 43 population controls without liver injury (HLC) and analysed using enzyme-linked immunosorbent assay (ELISA) or single-molecule arrays.ResultsAll biomarkers differentiated DILI and ALI from HLC with an area under receiver operator characteristic curve (AUC) value of >0.75 but were less efficient in distinguishing DILI from ALI, with ccK18 (0.79) and K18 (0.76) demonstrating highest potential. However, the AUC improved considerably (0.98) for ccK18 when comparing DILI and a subgroup of autoimmune hepatitis cases. Cytokeratin-18, microRNA-122 and α-glutathione-S-transferase correlated well with traditional transaminases, while osteopontin correlated most strongly with the international normalized ratio (INR).ConclusionsccK18 appears promising in distinguishing DILI from autoimmune hepatitis but less so from other forms of acute liver injury. Osteopontin demonstrates prognostic potential with higher levels detected in more severe cases regardless of aetiology.
PB Wiley
YR 2023
FD 2023
LK https://hdl.handle.net/10630/26374
UL https://hdl.handle.net/10630/26374
LA eng
NO Cueto-Sánchez A, Niu H, Álvarez-Álvarez I, López-Longarela B, Del Campo-Herrera E, Ortega-Alonso A, García-Cortés M, Pinazo-Bandera J, Sanabria-Cabrera J, Díaz-Mochón JJ, Lucena MI, Andrade RJ, Stephens C, Robles-Díaz M. Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage. Br J Clin Pharmacol. 2023 Mar 25. doi: 10.1111/bcp.15724. Epub ahead of print. PMID: 36965054.
NO Consejería de Salud y Familia de la Junta deAndalucía, Grant/Award Numbers: PI 0274-2016, P18-RT-3364; Instituto de Salud Carlos III (ISCIII) cofounded by Fondo Europeo de Desarrollo Regional - FEDER, Grant/Award Numbers: PI19/00883, PI18/00901,UMA18-FEDERJA-193; Universidad de Málaga/CBUA for open access charge: Universidad de Málaga / CBUA.Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026