RT Journal Article
T1 Hospitalised children with COVID-19 display an aberrant intestinal microbiota and a shift in faecal compounds related with the metabolism of vitamins and lipids
A1 Sanz, Miriam
A1 Gutiérrez- Díaz, Isabel
A1 González, Héctor
A1 Velasco Rodríguez‐Belvís, Marta
A1 Picáns-Leis, Rosaura
A1 Jiménez, Santiago
A1 González-Jiménez, David
A1 Rodríguez, Jorge
A1 Queralt, Macarena
A1 Herrador, Marta
A1 Martin‐Masot, Rafael
A1 Ferrer, Pablo
A1 Navas-López, Víctor Manuel
A1 Espín, Beatriz
A1 Leis, Rosaura
A1 Díaz, Juan J
A1 Delgado, Susana
K1 Niños - Efectos de la COVID-19
K1 Flora intestinal - Investigación
AB The SARS-CoV-2 virus and its rapid spread have made it a global health concern. The aim of this was to investigate the microbial and metabolic faecal profiles of paediatric patients hospitalised for COVID-19 to try to identify biomarkers of predisposition to severity. The study included 16 patients (aged 4–14 years old) from six different Spanish hospitals and 20 age-matched healthy controls. The gut microbiota was characterised by sequencing of 16S rDNA amplicons and internal transcribed space amplicons, while the metabolic profile was analysed by liquid chromatography high resolution mass spectrometry. A different microbial profile was observed between patients and controls, with a significantly higher abundance of sequences belonging to the phyla Bacteroidota and Pseudomonadota in patients. A different metabolic profile was observed between the two groups. Non-infected children had higher faecal levels of vitamins such as niacin, thiamine, and vitamin D3 derivatives, which were negatively correlated with the abundance of pathogenic bacteria, such as members of Enterobacteriaceae. Hospitalisation due to SARS-CoV-2 infection in children was associated with changes in the gut microbiota and an altered metabolomic profile. For the first time, several relevant biological compounds were found to be reduced in the faeces of children hospitalised with COVID-19 compared to healthy controls.
PB Plos one
YR 2025
FD 2025-05
LK https://hdl.handle.net/10630/38695
UL https://hdl.handle.net/10630/38695
LA eng
NO Sanz M, Gutiérrez-Diaz I, González H, Rodríguez-Belvís MV, Picáns-Leis R, Jiménez S, et al. (2025) Hospitalised children with COVID-19 display an aberrant intestinal microbiota and a shift in faecal compounds related with the metabolism of vitamins and lipids. PLoS One 20(5): e0323910
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026