RT Journal Article
T1 Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat
A1 Lara-Muñoz, José Pablo
A1 Dawid-Milner, Marc Stefan
A1 López-González, Manuel Víctor
A1 Montes, Carmen
A1 Spyer, KM
A1 González-Barón, Salvador
K1 Respiración - Regulación - Modelos animales
K1 Laringe - Modelos animales
K1 Experimentación animal
AB In order to study the importance of two pontine regions modulating laryngeal resistance, electrical current or microinjections of glutamate (10–30 nl, 1–3 nmol) were made into the pontine parabrachial complex and the A5 region in spontaneously breathing anaesthetized rats. Two distinct patterns of laryngeal and respiratory responses were elicited. An increase of subglottal pressure was accompanied with an expiratory facilitatory response consisted of a decrease in both respiratory rate and phrenic nerve activity. A decrease of subglottal pressure was accompanied with an inspiratory facilitatory response consisted of an increase in both respiratory rate and phrenic nerve activity. The modification of laryngeal calibre occurred during both respiratory phases in most cases. The concomitant cardiovascular changes of these responses were also analyzed. Controls using guanethidine to block autonomic responses which might interact with respiratory control were also made. Histological analysis of stimulation sites showed a topographical organization of these responses: laryngeal constriction was evoked from Kölliker–Fuse, medial parabrachial nuclei and A5 region, whilst the laryngeal dilation was evoked from the lateral parabrachial nucleus.
PB Elsevier
YR 2002
FD 2002
LK https://hdl.handle.net/10630/29448
UL https://hdl.handle.net/10630/29448
LA eng
NO J.P Lara, M.S Dawid-Milner, M.V López, C Montes, K.M Spyer, S González-Barón, Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat, Brain Research, Volume 934, Issue 2, 2002, Pages 97-106, ISSN 0006-8993, https://doi.org/10.1016/S0006-8993(02)02364-8.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026