RT Journal Article
T1 An olefin cross-metathesis approach to depudecin and stereoisomeric analogues
A1 Cheng-Sánchez, Iván
A1 García-Ruiz, Cristina
A1 Guerrero Vásquez, Guillermo A.
A1 Sarabia-García, Francisco Ramón
K1 Polímeros
AB A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, which provides for an efficient and improved access to natural depudecin, compared with our previous linear synthesis. Featured by its brevity and convergency, our developed synthetic strategy was applied to the preparation of the 10-epi derivative and the enantiomer of depudecin, which represent interesting stereoisomeric analogues for structure–activity
PB ACS
YR 2017
FD 2017
LK https://hdl.handle.net/10630/34594
UL https://hdl.handle.net/10630/34594
LA eng
NO Cheng-Sánchez, I.; García-Ruiz, C.; Guerrero-Vasquez, G.; Sarabia, F. An olefin cross-metathesis approach to depudecin and stereoisomeric analogues. J. Org. Chem. 2017, 82, 9, 4744-4757 https://doi.org/10.1021/acs.joc.7b00424
NO This work was financially supported by the Ministerio de Economı́a y Competitividad (MINECO) (ref CTQ2014-60223-R). I.C.-S. thanks Ministerio de Educación, Cultura y Deporte, for a predoctoral fellowship (FPU programme). G.A.G.-V. thanks University of Málaga for a postdoctoral fellowship (ICE-Andalucia TECH programme). The authors thank Dr. J. I. Trujillo from Pfizer (Groton, CT) for assistance in the preparation of this manuscript. The authors thank the Unidad de Espectroscopía de Masas and the NMR facility of the University of Málaga for exact mass and NMR spectroscopic assistance.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026