RT Journal Article
T1 Deciphering the Involvement of the Epicardium in Cardiac Diseases.
A1 Carmona-Mejías, Rita María
A1 López-Sánchez, Carmen
A1 García-Martínez, Virginio
A1 García-López, Virginio
A1 Muñoz-Chápuli-Oriol, Ramón
A1 Lozano-Velasco, Estefanía
A1 Franco, Diego
K1 Corazón - Enfermedades
K1 Arritmia
K1 Tejido adiposo
K1 Etiología médica
AB The epicardium is a very dynamic cardiac layer with pivotal contributions during cardiogenesis,acting in the postnatal period as an apparently dormant single-cell layer. In mammalianembryos, the epicardium, which originates form the proepicardium, translocates into the pericardialcavity and subsequently rests on the surface of the myocardium. Later, it gives rise to the epicardiumderivedcells, which migrate into subepicardial space, invade the developing myocardium, promotingits growth, and contribute to different cell types. Anomalies in the process of epicardial development,the generation of epicardium-derived cells and their signaling mechanisms in different experimentalmodels lead to defective cardiac development, reminiscent of human congenital heart diseases.Furthermore, recent studies have reported that epicardial derivates in adults, i.e., epicardial adiposetissue, are associated with electrophysiological cardiovascular anomalies. Herein, we provide astate-of-the-art review focusing on both congenital and adult heart diseases associated with epicardialdevelopment.
PB MDPI
YR 2023
FD 2023
LK https://hdl.handle.net/10630/38981
UL https://hdl.handle.net/10630/38981
LA eng
NO Carmona, R.; López- Sánchez, C.; García-Martinez, V.; García-López, V.; Muñoz-Chápuli, R.; Lozano-Velasco, E.; Franco, D. Deciphering the Involvement of the Epicardium in Cardiac Diseases. Hearts 2023, 4, 81–93. https:// doi.org/10.3390/hearts4040011
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026