2026-06-05T15:41:39Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/107292026-02-03T11:48:23Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Fernández-Domínguez, María Carmen
author
López-García, Alejandro
author
Soto-Navarrete, María Teresa
author
Durán-Boyero, Ana Carmen
author
Fernández-Corujo, Borja
2015-11-26T08:02:39Z
2015-11-26T08:02:39Z
2015
Lab Anim 49 (S3) 2015: 61 (ID:63)
http://hdl.handle.net/10630/10729
https://orcid.org/0000-0002-3293-9384
Incidence and type of bicuspid aortic
valve in two model species.
MC Fernández 1,2, A López-García 1,2, MT Soto 1,
AC Durán 1,2 and B Fernández 1,2.
1 Department of Animal Biology, Faculty of Science, University of Málaga, Spain.
2 Biomedical Research Institute of Málaga (IBIMA),
University of Málaga, Spain.
Bicuspid aortic valve (BAV) is the most frequent human congenital cardiac malformation, with an incidence of 1–2% worldwide. Two morphological types exist: type A (incidence 0.75–1.25%) and type B (incidence 0.25–0.5%), each with a distinct aetiology and natural history. Currently, ten animal models of BAV have been described in two different rodent species: one spontaneous Syrian hamster (Mesocricetus auratus) model of BAV type A and nine mutant laboratory mouse (Mus musculus) models of BAV type B. It remains to be elucidated whether the mutations leading to BAV in these models are typespecific or whether there are inter-specific differences regarding the type of BAV that hamsters, mice and humans may develop.
To solve this issue, we have characterized the incidence and types of BAVs in four inbred, two outbred and two hybrid lines of Syrian hamsters (n=4,340) and in three inbred, three outbred and one hybrid lines of laboratory mice (n=1,661) by means of stereomicroscopy and scanning electron microscopy. In addition, we have reviewed and calculated the incidence and type of BAVs in the published papers dealing with this anomaly in mice.
Our results indicate that the Syrian hamster develops BAVs type A and B including a variety of morphologies comparable to those of humans, whereas the mouse develops only BAVs type B with a short spectrum of valve morphologies. Thus, inter-specific differences between human and mouse aortic valves must be taken into consideration when studying valve disease in murine models.
This work was supported by P10-CTS-6068.
eng
by-nc-nd
Corazón - Enfermedades
Animales de laboratorio
Incidence and type of bicuspid aortic valve in two model species
conference output
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URL
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95ad41f54ef065d92631743812458aad
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application/pdf
Summary Incidencia VAB.pdf