2026-05-30T01:33:30Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/116762026-02-03T12:02:04Zcom_10630_2254col_10630_37959

Synthesis of fluorescent dendrimeric antigen efficiently internalized by human dendritic cells Mesa-Antunez, Pablo Collado-Martín, Daniel Vida-Pol, Yolanda Nájera-Albendín, Francisco Fernández-Duarte, Tahía Diana Torres-Jaén, María Josefa Pérez-de-Inestrosa-Villatoro, Ezequiel Biomoléculas Biopolímeros A new fluorescent dendrimeric antigen (DeAn) based on a dendron with amoxicilloyl terminal groups has been synthetized. The synthesis implies a novel class of all-aliphatic polyamide dendrimer (BisAminoalkylPolyAmide Dendrimers, or BAPAD).[1] The introduction of a cystamine core allows the incorporation of this dendrons into a 1,8-naphthalimide fluorofore functionalized with a maleimide group. The fluorescence properties of this DeAn has been studied and compared with the properties of an equivalent dendron possessing amino-terminal groups. This DeAn has been used as a synthetic antigen in a biomedical assay that tests the amoxicillin sensitivity of dendritic cells (DC) from tolerant and allergic patients. 2016-06-28T07:08:02Z 2016-06-28T07:08:02Z 2016 2016 conference output http://hdl.handle.net/10630/11676 http://orcid.org/orcid.org/0000-0002-1635-5514 spa XXVI Reunión Bienal de Química Orgánica Punta Umbría (Huelva, Spain) 06/2016 open access by-nc-nd Servicio de Publicaciones de la Universidad de Huelva