2026-05-27T04:49:59Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/146312026-02-03T11:33:28Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
García-Vilas, Javier A.
author
Pino-Ángeles, Almudena
author
Martínez-Póveda, Beatriz Amparo
author
Rodríguez-Quesada, Ana María
author
Medina-Torres, Miguel Ángel
2017-10-13T09:41:12Z
2017-10-13T09:41:12Z
2017-01
Cancer Letters 358 (2017) 1-11
http://hdl.handle.net/10630/14631
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we
show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics
simulation approach allows getting further insight on the inhibitory effect of damnacanthal on
three different kinases: vascular endothelial growth factor receptor-2, c-Met and focal adhesion
kinase. Several of the kinases targeted and inhibited by damnacanthal are involved in
angiogenesis. Ex vivo and in vivo experiments clearly demonstrate that, indeed, damnacanthal
is a very potent inhibitor of angiogenesis. A number of in vitro assays contribute to determine
the specific effects of damnacanthal on each of the steps of the angiogenic process, including
inhibition of tubulogenesis, endothelial cell proliferation, survival, migration and production of
extracellular matrix remodeling enzyme. Taken altogether, these results suggest that
damancanthal could have potential interest for the treatment of cancer and other angiogenesisdependent
diseases.
eng
by-nc-nd
Cancer
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
journal article
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URL
https://riuma.uma.es/bitstreams/d51e7e0f-f8b5-47ea-8e4a-90c4ba2002bf/download
File
MD5
2fd19b639e98668675afa0394daf9079
11847987
application/pdf
2017-01-Accepted manuscript-Cancer Letters.pdf