2026-05-27T05:35:43Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/149772026-02-03T12:06:44Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Ginés-Molina, María José
author
Luque, Rafael
author
Moreno-Tost, Ramón
author
Maireles-Torres, Pedro Jesús
2017-12-22T09:49:26Z
2017-12-22T09:49:26Z
2017-12-22
https://hdl.handle.net/10630/14977
Isosorbide is one of the most promising products derived from sorbitol. It has already found many applications, mainly in the polymer industry and medicine, such as isosorbide polycarbonate1 (DURABIO®) and isosorbide nitrates as vasodilator for angina pectoris2. The methylation of the two hydroxyl groups of isosorbide molecule gives rise to the formation of dimethyl isosorbide (DMI), which is a high boiling solvent (235ºC), used in skin care formulations because of its solubilising capacity and performance enhancing of many different topical skin actives3. Currently, DMI synthesis implies the use of methyl halides or dimethyl sulfate. A safer and more environmental benign approach has been proposed by Tundo et al4 by employing dimethylcarbonate (DMC) as both reactant and solvent in the presence of sodium methoxide.
In the present work, the synthesis of DMI in an excess of DMC by using a MgAl mixed oxides (MgAlOx), as heterogeneous catalyst, under mild reaction conditions, is proposed.
eng
Química inorgánica - Congresos
Green approach to the Isosorbide Conversion into Dimethyl isosorbide
conference output
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URL
https://riuma.uma.es/bitstreams/84e3280c-7a20-4ce2-a740-5ef9dd781813/download
File
MD5
e893361beca80bcf5240a3505ca57aae
247114
application/pdf
Gines_Maria_OO.pdf