2026-05-27T05:24:12Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/157672026-02-03T11:59:07Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
López-Unzu, Miguel A.
author
Rodríguez, Cristina
author
Lorenzale, Miguel
author
Fernández-Corujo, Borja
author
Durán-Boyero, Ana Carmen
2018-05-21T07:34:57Z
2018-05-21T07:34:57Z
2018-05-21
https://hdl.handle.net/10630/15767
Currently, three types of ventricular myoarchitecture are recognized in vertebrates, namely compact, spongy (trabeculated) and mixed myocardium. Mixed myocardium, which has been recently proposed as the primitive condition in gnathostomes, is composed of two myocardial layers: an inner trabeculated and an outer compact one. The trabeculation process has been studied in teleosts, showing exclusively spongy myocardium, and mammals and birds, characterized by a compact myocardial ventricular wall. In zebrafish, mouse and chicken embryos, the trabeculae develop as luminal myocardial ridges protruding into the lumen. In mammals and birds, further compactation of trabeculae leads to the formation of a compact layer. The potential mechanisms that may contribute to the formation of the ridges are under discussion and include myocardial proliferation, endocardial invagination, and bending of the entire myocardial layer. However, no description of the development of the mixed myocardium is available.
To shed some light on this issue, we have studied the heart development of an elasmobranch species with mixed myocardium, the lesser spotted dogfish (Scyliorhinus canicula; Chondrichthyes), by means of histological and immunohistochemical techniques for light microscopy, semithin sections, scanning electron microscopy and transmission electron microscopy.
Our results suggest that in the dogfish the intertrabecular spaces develop by connections between early intramyocardial spaces and the lumen of the ventricle through invaginations of the endocardial line. Chondrichthyans are the earliest diverged lineage of gnathostomes and, consequently, they have the most primitive cardiac design. Although chicken, mouse, and recently zebrafish have been considered powerful vertebrate models to study heart development, we propose that the trabeculation process in the dogfish is representative of the early steps of the ventricular morphogenesis in vertebrates.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Vertebrados - Corazón
Condrictios
Myocardial trabeculation in embryos of Scyliorhinus canicula (Elasmobranchii, Chondrichthyans)
conference output
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URL
https://riuma.uma.es/bitstreams/29a0951d-6286-4166-b464-59685d467532/download
File
MD5
917b544be4700c997eaa0b9aedc3e359
90398
application/pdf
Trabec Myoc EB 2018.pdf