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oai:riuma.uma.es:10630/166632026-02-03T11:09:58Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Romero-Sánchez, Lilian B. author Mari-Beffa, Manuel author Carrillo Fernández, Paloma author Medina-Torres, Miguel Ángel author Díaz-Cuenca, Aránzazu author 2018-10-19 The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more than three decades. This element can be incorporated to delivery carriers, such as BGs, and the materials used in biological assays. In this work, Cu-containing mesoporous bioactive glass (MBG) in the SiO2-CaO-P2O5 compositional system was prepared incorporating 5% mol Cu (MBG-5Cu) by replacement of the corresponding amount of Ca. The biological effects of the ionic products of MBG biodegradation were evaluated on a well-known endothelial cell line, the bovine aorta endothelial cells (BAEC), as well as in an in vivo zebrafish (Danio rerio) embryo assay. The results suggest that ionic products of both MBG (Cu free) and MBG-5Cu materials promote angiogenesis. In vitro cell cultures show that the ionic dissolution products of these materials are not toxic and promote BAEC viability and migration. In addition, the in vivo assay indicates that both exposition and microinjection of zebrafish embryos with Cu free MBG material increase vessel number and thickness of the subintestinal venous plexus (SIVP), whereas assays using MBG-5Cu enhance this effect. https://hdl.handle.net/10630/16663 10.1016/j.actbio.2017.12.032 Neovascularización Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model