2026-06-01T03:35:21Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/179352026-02-03T12:21:06Zcom_10630_2254col_10630_37959

Ojeda-Pérez, Betsaida Páez-González, Patricia Jiménez-Lara, Antonio Jesús 2019-07-03T11:06:59Z 2019-07-03T11:06:59Z 2019-07-03 https://hdl.handle.net/10630/17935 Introduction: In premature newborns, intraventricular hemorrhages (IVH) probably trigger the disruption of the neurogenic ventricular zone. Most of the cases with severe IVH develop post-hemorrhagic hydrocephalus (PHH). A mouse model with IVH has been developed to research into the common neuropathological events present in PHH and into possible therapies. Methods: In two-day-old mice, the blood serum from littermates was injected into the ganglionic eminence of one hemisphere or both hemispheres. Fourteen days later, a histopathological analysis was carried out. In the case of injection in one hemisphere, the effects were compared with the contralateral non-injected hemisphere. Results: Mice with IVH developed the following neuropathological effects. The ependyma was found denuded and replaced by reactive astrocytes. A reaction of astrocytes over-expressing aquaporin-4 and of NG2 cells was also found developed in the white matter. Alterations in the neurogenesis were also common in the ventricular zone and in the white matter. Conclusions: The animal model of IVH developed shows similar neuropathological events to other forms of congenital hydrocephalus and can be used to research into therapies for PHH. eng open access Espina bífida -- Congresos Hidrocefalia -- Congresos Neuropathological events in an animal model resembling human fetal post-hemorrhagic hydrocephalus conference output