2026-05-30T04:49:26Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/183022026-02-03T12:22:33Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Narváez-Peláez, Manuel
author
Santín-Núñez, Luis Javier
author
Tif, Maria
author
Fuxe, Kjell
author
Borroto Escuela, Dasiel Óscar
2019-09-11T09:02:44Z
2019-09-11T09:02:44Z
2019-09-11
https://hdl.handle.net/10630/18302
Neurogenesis persists in the hippocampus throughout the lifespan in a wide variety of species including humans. Within the dentate gyrus of the hippocampus, the subgranular zone (SGZ) is maintained as a stem cell niche. We have previously shown that Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation. To examine the acute effects of GALR2/NPYY1R interactions on newborn cells proliferation we analyzed the effects of the intracerebroventricular (icv) of single injections with GAL and NPYY1 agonists or coadministered. Male Sprague-Dawley rats (n = 6-8 per group) were randomly assigned to the groups. Each group received i.c.v. injections of artificial Cerebro Spinal Fluid (aCSF), GAL or NPYY1R agonist [Leu31,Pro34]NPY alone or in combination. Intraperitoneal (ip) injections of exogenous cell DNA marker 5-bromo-2-deoxyuridine (BrdU) 50mg/Kg were made at 2 and 4 hours after icv injections and 24 hours later rats were anesthetized, transcardially perfused and the brains collected for immunostaining to evaluate cell proliferation. Coadministration of GAL and NPYY1R agonist increased BrdU-labeled cells located in the SGZ (P<0,001) compared with aCSF, GAL and the NPYY1R-mediated hippocampal cell proliferation, These results will contribute to a better knowledge of the potential role of GAL and NPY family in mediating neurogenic actions and may give the basis for the therapeutic potential of targeting the GAL and NPY system in depressive disorders. Study supported by
Proyecto Crowfunding “Más Neuronas, menos depression” Universidad de Málaga. Acknowledgements to Catalina, Héctor Pittman Villarreal and Francisco Rodriguez López.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Neurogénesis
Improvement on hippocampal neuroproliferation through galanin and neuropeptide y y1 receptor agonist interaction
conference output
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URL
https://riuma.uma.es/bitstreams/042943e6-2dac-4284-90af-248cd6ca27cc/download
File
MD5
000ff10af4bf4d8c59dae02d4d444b4a
21611
application/pdf
IMPROVEMENT ON HIPPOCAMPAL NEUROPROLIFERATION .pdf