2026-05-27T04:50:04Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/183212026-02-03T12:01:35Zcom_10630_2254col_10630_37959

New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose Collado-Martín, Daniel Pérez-de-Inestrosa-Villatoro, Ezequiel Ruiz-Sanchez, Antonio Jesus Mayorga Mayorga, Cristobalina Torres-Jaén, María Josefa Alergia a los medicamentos Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to avoid the use of unnecessary alternative antibiotics that may reduce efficacy, lead to prolonged treatments, have a higher toxicity or induce bacterial resistance. The most consensual approach to diagnose betalactam allergy are in vivo tests. However, they are not risky free, require experienced personnel and are both time-consuming and expensive for health-care systems, being so in vitro test more appropriate or complementary to the in vivo tests. In vitro tests are not still widely used on account of their low sensitivity. Current efforts are in progress to improve these assays, thus allowing for better diagnosis of allergic responses within patients. REF 2 We report progress in the preparation of new functional materials for in vitro allergic diagnosis testing. In particular, the application of new approaches employing orthogonally functionalised fluorescent dyes based upon 4-amino-1,8 naphthalimide joined with the multivalence of polyamide dendrimers. REF 3 The in vitro diagnosis capabilities of these functional materials was verified by testing on patient sera samples, with results demonstrating their potential for application within the healthcare industry. Acknowledgments: The present study has been supported by MINECO CTQ2016-75870P; by Andalusian Regional Ministry Health (grants: PI-0250-2016); by the European Regional Development Fund (ERDF) and “Plan Propio Universidad de Málaga” (UMA-Andalucía-TECH). 2019-09-11T12:33:53Z 2019-09-11T12:33:53Z 2019-09-11T12:33:53Z 2019-09-11 conference output https://hdl.handle.net/10630/18321 eng 5th World Congress on Electrical Engineering and Computer Systems and Sciences Lisboa 22/08/2019 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional