2026-05-31T02:12:21Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/198672026-02-03T11:48:39Zcom_10630_2254col_10630_37959
Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose
Ruiz-Sanchez, Antonio Jesus
Collado-Martín, Daniel
Mayorga Mayorga, Cristobalina
Torres-Jaén, María Josefa
Pérez-de-Inestrosa-Villatoro, Ezequiel
Dendrímeros
Alergia a los medicamentos
β-lactams are the most widely drug prescribed against infections, but they are the most commonly
reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid
rejecting them by other more expensive broad-spectrum antibiotics, with potential risk factors for the
development of multiple drug-resistant bacteria. [1] Skin testing is the most consensual approach to
diagnose β-lactam allergy, but this in vivo test is not risky free and should be performed under strict
hospital surveillance.[2] In vitro testing is not still widely used on account of their low sensitivity. We
report the use of already haptenized fluorescent dendrimers [3] to control the preparation of materials
for in vitro test, and their verification by testing on patient sera samples. This fluorescent dendrimer is
obtained from a dye with two orthogonal functional groups suitable for click chemistry. [4]
Acknowledgments: This work was supported by: MINECO CTQ2016-75870P, Andalusian Regional
Ministry Health (PI-0250-2016); European Regional Development Fund and “Plan Propio Universidad
de Málaga” (UMA-Andalucía-TECH).
2020-10-01T09:00:01Z
2020-10-01T09:00:01Z
2020-10-01T09:00:01Z
2020-10-01
conference output
https://hdl.handle.net/10630/19867
eng
NANOPT ONLINE CONFERENCE (NPTO2020)
Online
23-24 septiembre 2020
http://creativecommons.org/licenses/by-nc-nd/4.0/
open access
Attribution-NonCommercial-NoDerivatives 4.0 Internacional