2026-05-29T23:40:41Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/205892026-02-03T12:05:46Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Mejías-Ortega, Marina
author
Sánchez-Mejías, Elisabeth
author
Núñez-Díaz, Cristina
author
Trujillo-Estrada, Laura Isabel
author
Sánchez-Varo, Raquel María
author
Dávila-Cansino, José Carlos
author
Gutiérrez-Pérez, Antonia
2020-12-16T07:49:39Z
2020-12-16T07:49:39Z
2020-12-16
https://hdl.handle.net/10630/20589
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, (PVMs), are also involved in neurodegeneration. However, the implication of myeloid cells in the human pathology have not been determined yet. Here, we analyzed the phenotypic profile displayed by these damage associated myeloid cells in the frontal cortex of AD brains. For this purpose, immunohistochemistry and image analysis approaches have been carried out in postmortem samples from non-demented controls and AD cases. Frontal cortex of AD patients showed strong myeloid activation similar to that observed in amyloidogenic mice. Microglial cells of Braak V VI patients were observed forming clusters and exhibited, both plaque and interplaque damage-associated
phenotype. Moreover, in these individuals the PVMs were localized in the parenchyma, predominantly located surrounding amyloid plaques. On the contrary, Braak II with mild amyloid pathology (CERAD B) cases presented only activated microglial cells, while, immunoreactivity of CD163 was absent.These strongly activated myeloid cells, could drive the AD pathology and, in consequence, could be implicated in the
pathology progression.Taken together, these findings suggest the existence of two populations of myeloid cells associated with Aβ plaques in the frontal cortex in the advanced stages of the pathology and probably due to failures in the integrity of the blood-brain barrier. The differential contribution of these two myeloid populations to the pathogenesis of the disease remains to be elucidated. These results open the opportunity to design targeted therapies, not only to microglia, but also to the population of macrophages, in order to modulate amyloid pathology and provide a better understanding of the immunological mechanisms underlying AD progression.
eng
Alzheimer, enfermedad de
Sistema nervioso - Degeneración
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
conference output
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Degenerative Diseases congreso 2020 Marina libro de abstract.pdf