2026-05-30T09:34:03Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/212912026-02-03T12:23:08Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Vegas-Gómez, Laura
author
Edwards III, George
author
Hasan, Omar
author
Gámez, Nazaret
author
Schulz, Jonathan
author
Soto, Claudio
author
Schulz, Paul
author
Moreno-González, Inés
2021-04-05T10:48:40Z
2021-04-05T10:48:40Z
2021
https://hdl.handle.net/10630/21291
Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of beta-amyloid protein (Aβ) and the formation of intraneuronal neurofibrillary tangles (NFT) composed of hyperphosphorylated tau (ptau), along with neuroinflammation and neuronal loss that ultimately induces to noticeable cognitive impairments. Abnormal ptau leads to the formation of insoluble, beta-sheet rich amyloid aggregates in tauopathies such as AD. Positron emission tomography (PET) imaging is a promising avenue that may identify tau aggregates in vivo cross-sectionally and longitudinally in various dementia conditions. Methods: The goal of this study is to characterize the longitudinal assessment of the tau tracer 18F-THK5351 by in vivo tau PET imaging concomitantly to behavior and tau pathology by histology and biochemistry from 6 to 12 months of age in tau transgenic P301S mice, a mouse model of tauopathies. Results: Our results demonstrate an augmentation of overall gross brain tau pathology by in vivo PET imaging in P301S mice compared to age-matched wild-type (WT) animals accompanied by P301S-model associated pathological tau and phenotypic and behavioral deficits. Conclusions: This longitudinal study provides new insights on the relationship between imaging diagnostic tools, the in vivo neuropathological temporal pattern and the clinical signs observed in animal models of AD that could benefit early disease diagnosis.
eng
Alzheimer, Enfermedad de
Tomografía de emisión
18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
conference output
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URL
https://riuma.uma.es/bitstreams/e246a7fd-2732-40c8-8dfb-b882b67be004/download
File
MD5
d224be4b6638da3a787112527f1feb55
132409
application/pdf
Vegas-Gomez ADPD2021.pdf