2026-05-31T03:11:04Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/224732026-02-03T12:39:27Zcom_10630_2254col_10630_37957

Silicon Photonics Mach-Zehnder Biosensor with Coherent Detection for Point-of-Care Devices Leuermann, Jonas Molina-Fernández, Íñigo Halir, Robert Interferómetros laser Silicon Photonics Biosensor Point-of-Care Allergy Detection One important aspect is its immunity to laser phase noise and relative intensity noise. That means that inexpensive fixed wavelength Fabry-Perot lasers can be used with this type of sensor. This reduces the cost of the light source tremendously. Within this work it was demonstrated that it can reach cutting-edge state-of-the-art detection limits in typical bulk sensing and biosensing (with C-reactive protein) performance verification. Finally, targeting a real application scenario, the specific detection of IgG and IgE amoxicillin antibodies was demonstrated applying amoxicillin haptenised PAMAM G2 dendrimers on the sensing area. Integrated photonic biosensors are a highly promising technology platform for biochemical diagnostics. In general, they have demonstrated impressively low detection limits and can offer highly multiplexed operations in real time. Ring-resonator-based photonic biosensors have been shown to be a practical solution for lab-on-chip solutions and first commercial products are already available. However, they mostly require an expensive high-quality laser for accurate operation. In recent years, interferometer-based photonic sensors have demonstrated even lower detection limits as well as multiplexation capabilities and are candidates for future point-of-care devices for primary care, directly at the patient site. Point-of-care solutions require a portable and inexpensive device. The read-out, i.e. optical source, detection scheme, and signal processing, typically make up a significant part of an integrated photonic biosensor system’s price. Ring-resonator-based systems often need a tunable narrow-linewidth laser as optical source to extract the resonance wavelength, whereas interferometers just need a fixed wavelength source to accurately extract the phase shift, but can suffer from sensitivity fading and ambiguity. In this thesis we investigate a coherently read symmetric Mach-Zehnder interferometer that overcomes these drawbacks and show that it is an attractive solution for point-of-care devices for several reasons. 2021-06-16T11:02:48Z 2021-06-16T11:02:48Z 2021-04-16 2021-06-16 2021-05-07 doctoral thesis https://hdl.handle.net/10630/22473 eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf UMA Editorial