2026-05-30T03:26:25Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/227472026-02-03T11:34:35Zcom_10630_2254col_10630_37953

Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine Mañas-Padilla, María del Carmen Ávila-Gámiz, Fabiola Gil-Rodríguez, Sara Ladrón de Guevara-Miranda, David Rodriguez-de-Fonseca, Fernando Santín-Núñez, Luis Javier Castilla-Ortega, María Estela Ansiedad Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely reported. In this study, mice were administered with cocaine (20 mg/kg/day) or vehicle for 12 consecutive days. After 24 days of drug abstinence, a behavioral assessment was carried out in drug-free conditions and in unfamiliar environments (i.e. no cocaine-associated cues were presented). The cocaine-withdrawn mice showed cognitive deficits in spontaneous alternation behavior and place recognition memory. Importantly, they also displayed hyperlocomotion, increased rearing activity and altered exploratory patterns in different tasks. In the forced swimming test, they were more active (struggled/climbed more) when trying to escape from the water albeit showing normal immobility behavior. In conclusion, in addition to cognitive deficits, chronic cocaine in rodents may induce long-lasting alterations in exploratory activity and psychomotor activation that are triggered even in absence of drug-related stimuli. 2021-08-26T11:29:56Z 2021-08-26T11:29:56Z 2021 journal article https://hdl.handle.net/10630/22747 10.1016/j.physbeh.2021.113542 eng open access Elsevier