2026-06-01T02:18:09Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/235052026-02-03T10:56:57Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Atallah, Edmond author Freixo, Cristiana author Álvarez-Álvarez, Ismael author Cubero, Francisco Javier author Gerbes, Alexander L author Kullak-Ublick, Gerd A author Aithal, Guruprasad P. author 2021-11-15 Introduction: Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. Areas covered: This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or prognosis of DILI. Following a comprehensive search, we included all types of studies in humans. We included DILI cases based on any threshold criteria but excluded intrinsic DILI, commonly caused by paracetamol overdose. We classified studies into diagnostic and prognostic categories and assessed their methodological quality. After reviewing the literature, 14 studies were eligible. Expert Opinion: Diagnostic studies were heterogeneous with regard to the study population and outcomes measured. Prognostic models were developed by integrating novel biomarkers, risk scores, and traditional biomarkers, which increased their prognostic ability to predict death or transplantation by 6 months. This systematic review highlights the case of need for non-genetic biomarkers that distinguish DILI from acute liver injury related to alternative etiology. Biomarkers with the potential to identify serious adverse outcomes from acute DILI should be validated in independent prospective cohorts with a substantial number of cases. Edmond Atallah, Cristiana Freixo, Ismael Alvarez-Alvarez, F.J Cubero, Alexander L. Gerbes, Gerd A. Kullak-Ublick & Guruprasad P. Aithal (2021) Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review, Expert Opinion on Drug Metabolism & Toxicology, 17:11, 1327-1343, DOI: 10.1080/17425255.2021.1999410 https://hdl.handle.net/10630/23505 10.1080/17425255.2021.1999410 Hígado -- Enfermedades Medicamentos Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review