2026-05-28T06:18:07Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/236252026-02-03T11:18:19Zcom_10630_2254col_10630_37953

Stephens, Camilla Robles-Díaz, María Mercedes Medina-Cáliz, Inmaculada García-Cortés, Miren Ortega-Alonso, Aida Sanabria-Cabrera, Judith Adriana González-Jiménez, Andrés Álvarez-Álvarez, Ismael Slim, Mahmoud Jiménez-Pérez, Miguel González-Grande, Rocío Fernández, M. Carmen Casado, Marta Soriano, German Roman, Eva Hallal, Hacibe Romero-Gomez, Manuel Castiella, Agustin Conde, Isabel Prieto, Martin Moreno-Planas, José María Giraldez, Alvaro Moreno-Sanfiel, J Miguel Kaplowitz, Neil Lucena-González, María Isabel Andrade-Bellido, Raúl Jesús 2022-01-17T12:07:00Z 2022-01-17T12:07:00Z 2021-02-01 Stephens C, Robles-Diaz M, Medina-Caliz I, Garcia-Cortes M, Ortega-Alonso A, Sanabria-Cabrera J, Gonzalez-Jimenez A, Alvarez-Alvarez I, Slim M, Jimenez-Perez M, Gonzalez-Grande R, Fernández MC, Casado M, Soriano G, Román E, Hallal H, Romero-Gomez M, Castiella A, Conde I, Prieto M, Moreno-Planas JM, Giraldez A, Moreno-Sanfiel JM, Kaplowitz N, Lucena MI, Andrade RJ; Participating clinical centres. Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry. J Hepatol. 2021 Jul;75(1):86-97. doi: 10.1016/j.jhep.2021.01.029. https://hdl.handle.net/10630/23625 10.1016/j.jhep.2021.01.029 Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into the Spanish DILI Registry over a 20-year time period. Methods: Cases were identified, diagnosed and followed prospectively. Clinical features, drug information and outcome data were collected. Results: A total of 843 patients, with a mean age of 54 years (48% females), were enrolled up to 2018. Hepatocellular injury was associated with younger age (adjusted odds ratio [aOR] per year 0.983; 95% CI 0.974-0.991) and lower platelet count (aOR per unit 0.996; 95% CI 0.994-0.998). Anti-infectives were the most common causative drug class (40%). Liver-related mortality was more frequent in patients with hepatocellular damage aged ≥65 years (p = 0.0083) and in patients with underlying liver disease (p = 0.0221). Independent predictors of liver-related death/transplantation included nR-based hepatocellular injury, female sex, higher onset aspartate aminotransferase (AST) and bilirubin values. nR-based hepatocellular injury was not associated with 6-month overall mortality, for which comorbidity burden played a more important role. The prognostic capacity of Hy's law varied between causative agents. Empirical therapy (corticosteroids, ursodeoxycholic acid and MARS) was prescribed to 20% of patients. Drug-induced autoimmune hepatitis patients (26 cases) were mainly females (62%) with hepatocellular damage (92%), who more frequently received immunosuppressive therapy (58%). eng open access Hepatitis Epidemiología Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry journal article