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Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments Castilla-Ortega, María Estela Santín-Núñez, Luis Javier Toxicomanía Neurobiología del desarrollo Hipocampo (Cerebro) Author manuscript Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate AHN has led to escalating interest in the potential involvement of AHN in drug addiction over the last decade, with cocaine being one of the most frequently investigated drugs. This review argues that, unlike other drugs of abuse, preclinical evidence does not, overall, support that cocaine induces a marked or persistent impairment in AHN. Nevertheless, experimental reduction of AHN consistently exacerbates vulnerability to cocaine. Interestingly, preliminary evidence suggests that, on the contrary, increasing AHN might help both to prevent and treat addiction. 2022-03-07T12:37:24Z 2022-03-07T12:37:24Z 2020 journal article Castilla-Ortega, E., & Santín, L. J. (2020). Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments. Current Opinion in Pharmacology, 50, 109–116. https://doi.org/10.1016/J.COPH.2019.10.002 https://hdl.handle.net/10630/23837 https://doi.org/10.1016/J.COPH.2019.10.002 eng open access Elsevier