2026-06-06T01:51:50Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/239752026-02-03T11:15:53Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Cárdenas García, Casimiro author Torres-Vargas, José Antonio author Cárdenas Valdivia, Abel author Jurado, Nuria author Rodríguez-Quesada, Ana María author García-Caballero, Melissa author Martínez-Póveda, Beatriz Amparo author Medina-Torres, Miguel Ángel author 2021-11 The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds. Cárdenas, Casemiro ; Torres-Vargas, José Antonio ; Cárdenas Valdivia, Abel ; Jurado, Nuria ; Rodriguez-Quesada, Ana Maria ; García-Caballero, Melissa ; Martínez Poveda, Beatriz ; Medina Torres, Miguel Ángel. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomedicine & Pharmacotherapy Volume 144, December 2021, 112263. https://doi.org/10.1016/j.biopha.2021.112263 https://hdl.handle.net/10630/23975 10.1016/j.biopha.2021.112263 Neovascularización Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity