2026-05-31T05:43:51Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/239752026-02-03T11:15:53Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Cárdenas García, Casimiro
author
Torres-Vargas, José Antonio
author
Cárdenas Valdivia, Abel
author
Jurado, Nuria
author
Rodríguez-Quesada, Ana María
author
García-Caballero, Melissa
author
Martínez-Póveda, Beatriz Amparo
author
Medina-Torres, Miguel Ángel
2022-04-26T09:23:48Z
2022-04-26T09:23:48Z
2021-11
Cárdenas, Casemiro ; Torres-Vargas, José Antonio ; Cárdenas Valdivia, Abel ; Jurado, Nuria ; Rodriguez-Quesada, Ana Maria ; García-Caballero, Melissa ; Martínez Poveda, Beatriz ; Medina Torres, Miguel Ángel. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomedicine & Pharmacotherapy Volume 144, December 2021, 112263. https://doi.org/10.1016/j.biopha.2021.112263
https://hdl.handle.net/10630/23975
10.1016/j.biopha.2021.112263
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Neovascularización
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
journal article
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