2026-05-30T17:38:12Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/240602026-02-03T11:33:31Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Fernández-Santamaría, Rubén author Ariza Veguillas, Adriana author Fernández-Duarte, Tahía Diana author Céspedes Lagos, José Antonio author Labella, Marina author Mayorga Mayorga, Cristobalina author Torres-Jaén, María Josefa author 2021-10-07 The immunological mechanisms involved in drug hypersensitivity reactions (DHRs) are complex, and despite important advances, multiple aspects remain poorly understood. These not fully known aspects are mainly related to the factors that drive towards either a tolerant or a hypersensitivity response and specifically regarding the role of B and T cells. In this review, we focus on recent findings on this knowledge area within the last 2 years. We highlight new evidences of covalent and non-covalent interactions of drug antigen with proteins, as well as the very first characterization of naturally processed flucloxacillin-haptenated human leukocyte antigen (HLA) ligands. Moreover, we have analysed new insights into the identification of risk factors associated with the development of DHRs, such as the role of oxidative metabolism of drugs in the activation of the immune system and the discovery of new associations between DHRs and HLA variants. Finally, evidence of IgG-mediated anaphylaxis in humans and the involvement of specific subpopulations of effector cells associated with different clinical entities are also topics explored in this review. All these recent findings are relevant for the underlying pathology mechanisms and advance the field towards a more precise diagnosis, management and treatment approach for DHRs. Fernandez-Santamaria R, Ariza A, Fernandez TD, et al. Advances and highlights in T and B cell responses to drug antigens. Allergy. 2022;77:1129– 1138. https://doi.org/10.1111/all.15126 https://hdl.handle.net/10630/24060 10.1111/all.15126 Inmunología Advances and highlights in T and B cell responses to drug antigens