2026-05-27T04:46:08Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/244712026-03-13T08:00:59Zcom_10630_2254col_10630_37953

Sánchez-Varo, Raquel María Mejías-Ortega, Marina Fernández-Valenzuela, Juan José Núñez-Díaz, Cristina Cáceres Palomo, Laura Vegas-Gómez, Laura Sánchez-Mejías, Elisabeth Trujillo-Estrada, Laura Isabel Moreno-González, Inés García-León, Juan Antonio Vizuete, María Luisa Vitorica Ferrández, Javier Baglietto-Vargas, David Gutiérrez-Pérez, Antonia 2022-06-23T10:32:41Z 2022-06-23T10:32:41Z 2022-05-12 Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. International Journal of Molecular Sciences. 2022; 23(10):5404. https://doi.org/10.3390/ijms23105404 https://hdl.handle.net/10630/24471 10.3390/ijms23105404 Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor protein (APP) and presenilins (PS) genes. However, due to the repeated failure of translational applications from animal models to human patients, along with the recent advances in genetic susceptibility and our current understanding on disease biology, these models have evolved over time in an attempt to better reproduce the complexity of this devastating disease and improve their applicability. In this review, we provide a comprehensive overview about the major pathological elements of human AD (plaques, tauopathy, synaptic damage, neuronal death, neuroinflammation and glial dysfunction), discussing the knowledge that available mouse models have provided about the mechanisms underlying human disease. Moreover, we highlight the pros and cons of current models, and the revolution offered by the concomitant use of transgenic mice and omics technologies that may lead to a more rapid improvement of the present modeling batter eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Alzhéimer, Enfermedad de Sistema nervioso - Degeneración Neuroglia Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis journal article