2026-05-31T04:14:23Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/244852026-02-03T11:05:39Zcom_10630_2254col_10630_37953

Porras Alcalá, Cristina Moya-Utrera, Federico García-Castro, Miguel Sánchez-Ruiz, Antonio López-Romero, Juan Manuel Pino-González, María Soledad Díaz-Morilla, Amelia Kitamura, Seiya W. Wolan, Dennis Prados, Jose Melguizo, Consolación Cheng-Sánchez, Iván Sarabia-García, Francisco Ramón 2022-06-24T08:51:16Z 2022-06-24T08:51:16Z 2022-05-31 Porras-Alcalá C, Moya-Utrera F, García-Castro M, Sánchez-Ruiz A, López-Romero JM, Pino-González MS, Díaz-Morilla A, Kitamura S, Wolan DW, Prados J, Melguizo C, Cheng-Sánchez I, Sarabia F. The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria. Marine Drugs. 2022; 20(6):373. https://doi.org/10.3390/md20060373 https://hdl.handle.net/10630/24485 https://doi.org/10.3390/md20060373 The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry. eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Antibióticos The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria journal article