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00925njm 22002777a 4500 dc García-Ranea, Juan Antonio author Richard Perkins, James author Chagoyen, Mónica author Díaz-Santiago, Elena Dolores author Pazos, Florencio author 2022-06-17 Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where large numbers of genes are involved. The complex human pathological landscape is traditionally partitioned into discrete “diseases”; however, that partition is sometimes problematic, as diseases are highly heterogeneous and can differ greatly from one patient to another. Moreover, for many pathological states, the set of symptoms (phenotypes) manifested by the patient is not enough to diagnose a particular disease. On the contrary, phenotypes, by definition, are directly observable and can be closer to the molecular basis of the pathology. These clinical phenotypes are also important for personalised medicine, as they can help stratify patients and design personalised interventions. For these reasons, network and systemic approaches to pathologies are gradually incorporating phenotypic information. This review covers the current landscape of phenotype-centred network approaches to study different aspects of human diseases Ranea JAG, Perkins J, Chagoyen M, Díaz-Santiago E, Pazos F. Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View. Genes. 2022; 13(6):1081. https://doi.org/10.3390/genes13061081 https://hdl.handle.net/10630/24543 https://doi.org/10.3390/genes13061081 Genes Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View