2026-05-28T08:42:47Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/247612026-02-03T11:37:35Zcom_10630_2254col_10630_20092
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Cantero-García, Noelia
author
Flores-Burgess, Antonio
author
Ladrón de Guevara-Miranda, David
author
Serrano, Antonia
author
García-Durán, Laura
author
Puigcerver-Martínez, Araceli
author
Fuxe, Kjell
author
Narváez-Bueno, José Ángel
author
Santín-Núñez, Luis Javier
author
Díaz-Cabiale, Zaida
author
Millón-Peñuela, Carmelo
2022-07-25T09:19:51Z
2022-07-25T09:19:51Z
2022-07-25
https://hdl.handle.net/10630/24761
10.24310/riuma.24761
Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin (1–15) [GAL(1–15)] on escitalopram (ESC)-mediated effect in alcohol consumption using the alcohol self-administration test, the nuclei involved in the effect, and whether GAL(1–15) + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1–15) + ESC combination substantially reduced alcohol intake in the alcohol self-administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1–15) + ESC coadministration significantly decreases the number of C-Fos-IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1–15) reversed adverse ESC-mediated effects in the depression-related behavioural test and forced swimming test. The results open up the possibility of using GAL(1–15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression.
eng
Atribución-NoComercial-CompartirIgual 4.0 Internacional
Neuropsicofarmacología
Depresión mental
Alcoholismo
The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression
dataset
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URL
https://riuma.uma.es/bitstreams/3b7c6183-55b3-4f3b-9c64-5d45a6762c75/download
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Combination of Galanin (1–15) and Escitalopram .xlsx
URL
https://riuma.uma.es/bitstreams/65e7c3fe-90d4-439a-a14a-7a3d3e392cd5/download
File
MD5
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text/plain
ReadmeBiomedicines.txt