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                  <mods:namePart>Torres-Prioris, María José</mods:namePart>
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                  <mods:namePart>Melgar Mota, Ana</mods:namePart>
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                  <mods:namePart>Hohl, Ariane</mods:namePart>
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                  <mods:namePart>Gutiérrez-Cordero, Ismael</mods:namePart>
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                  <mods:namePart>Ariza-Corbo, María José</mods:namePart>
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                  <mods:namePart>Ortega Palacios, Ricardo</mods:namePart>
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                  <mods:namePart>Alfaro Rubio, Francisco</mods:namePart>
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                  <mods:namePart>Edelkraut, Lisa</mods:namePart>
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                  <mods:namePart>Berthier-Torres, Marcelo Luis</mods:namePart>
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                  <mods:namePart>Dávila-Arias, María Guadalupe</mods:namePart>
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                  <mods:dateAccessioned encoding="iso8601">2022-07-29T11:03:56Z</mods:dateAccessioned>
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               <mods:identifier type="uri">https://hdl.handle.net/10630/24799</mods:identifier>
               <mods:abstract>Objectives: &#xd;
(a) To evaluate the benefits promoted by two modalities of intensive language-action therapy, telerehabilitation (Tele-ILAT) and face-to-face (ILAT), applied alone and in combination with Donepezil to persons with chronic post-stroke aphasia (PSA) (phase 1). &#xd;
(b) To examine the best remote or hybrid strategy to maintain the gains in language and language-affiliated behaviours (communication, psychological adjustment, and quality of life) promoted by both modalities of ILAT, and to determine the efficacy of these interventions in reducing the therapist burden (phase 2).&#xd;
(c) To identify potential predictors of treatment response, including gene markers, and to detect changes in language,   cognition, emotional functions and neural plasticity using multimodal MRI. &#xd;
Methodology: &#xd;
Estimated sample size: 48 participants with chronic PSA are required to obtain a power of 80% (  increment of 5 points ± 4) relative to baseline scores on the Western Aphasia Battery-Revised.&#xd;
Methods and design: a randomized control trial involving four groups comparing the effectiveness of ILAT applied online, and face-to-face administered alone and with Donepezil (phase 1); three quasi-randomised parallel groups (asynchronous, hybrid and control) (phase 2). &#xd;
Results and conclusions: &#xd;
Primary outcome measures: aphasia severity, communication, behaviour, and quality of life.   Evaluations will determine potential predictive variables of response, as well as brain and language changes associated with the treatments at different timepoints. &#xd;
This trial will determine: (a) whether Tele-ILAT administered alone and combined with Donepezil reduces aphasia severity and language-affiliated deficits in the same manner as face-to-face ILAT and the contribution of adding Donepezil to these interventions; (b) the best long-term remote maintenance-therapy.</mods:abstract>
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               <mods:subject>
                  <mods:topic>Logoterapia</mods:topic>
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               <mods:subject>
                  <mods:topic>Lenguaje - Aspectos fisiológicos</mods:topic>
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               <mods:titleInfo>
                  <mods:title>Efficacy Of Intensive Tele-Rehabilitation Combined With Donepezil Compared To Face-to-face Administration</mods:title>
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               <mods:genre>conference output</mods:genre>
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