2026-06-04T23:34:20Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/248552026-03-13T08:00:35Zcom_10630_2254col_10630_37959

The effect of different amyloid seeds and animal hosts on amyloid propagation in Alzheimer's Disease Andreo-López, Juana Cantero-Molina, Francisco Bettinetti-Luque, Miriam Do Huynh, Kelly Thu Nguyen, Marie Minh Cheung, Alwin Pham Tran, Janine Trujillo-Estrada, Laura Isabel Núñez-Díaz, Cristina Martini, Alessandra C. Forner, Stefania Gutiérrez-Pérez, Antonia LaFerla, Frank Baglietto-Vargas, David Alzheimer, Enfermedad de Abstract text: Alzheimer's Disease is a neurodegenerative proteinopathy in which recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process of template protein corruption or seeding. In fact, studies show that Aβ deposition can be induced by the intracerebral infusion of seed-containing brain homogenates, and that the characteristics of both the seeding agent and the host, influence the pathologic signature of the Aβ seeds. However, it is still unknown which Aβ-misfolded species are most efficient in triggering the aggregation process and which is the effect of amyloid seeds on different AD models. Methods: Amyloid seeds from AD patients (stage C for amyloid) from the Alzheimer’s Disease Research Center (ADRC) at UCI were administered into 7-8-month-old hAβ-KI mice and 3xTg-AD mice. Next, we intracerebrally injected brain homogenates from the human AD patient and 25mo-3xTg-AD mice into the hippocampus of 7-month-old 3xTg-AD mice, which were analyzed at 18 months of age. Results: Our findings demonstrated that amyloid deposition differentially occurs in 3xTg-AD and hAβ-KI mice, and the Aβ aggregates are developed earlier in the familial model. Moreover, the amyloid seeds from the human patient induce more aggressive amyloid pathology compared to seeds from aged 3xTg-AD mice. Conclusion: These results suggest that multiple factors such as the seed, recipient model and time are critical factors that can modulate the amyloid pathology onset and progression. Thus, more profound understanding of these factors will provide key insight on how amyloid pathology progresses in AD. 2022-08-31T10:46:39Z 2022-08-31T10:46:39Z 2022-07-13 conference output https://hdl.handle.net/10630/24855 eng FENS Forum 2022 París, Francia 9-12 de Julio http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional