2026-05-28T19:49:37Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/250842026-02-03T11:46:27Zcom_10630_2254col_10630_37959

00925njm 22002777a 4500 dc Mirchandani-Duque, Marina author Barbancho-Fernández, Miguel Ángel author López-Salas, Alexander author Álvarez-Contino, José Erik author García-Casares, Natalia author Fuxe, Kjell author Borroto Escuela, Dasiel Óscar author Narváez-Peláez, Manuel author 2022-09-22 Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses the sustained memory performance and antidepressive-like effects induced by GALR2 and NPYY1R agonists coadministration and their neurochemical hippocampal correlates. Object-in-place task and forced swimming test were conducted together with in situ proximity ligation assay (PLA) to manifest the formation of GALR2/Y1R heteroreceptor complexes. We evaluated cell proliferation through a 5-Bromo-2’-deoxyuridine (BrdU) and PCNA expression study within the hippocampus. The GalR2 agonist M1145 and GAL were demonstrated to act with the Y1R agonist to improve memory retrieval and antidepressive-like actions at 24 hours in both tasks, enhancing the cell proliferation in the DG of the hippocampus through BrdU and PCNA expression and the GALR2/Y1R heteroreceptor complexes upon agonist coactivation. Our results may provide the basis for developing heterobivalent agonist pharmacophores targeting Y1R-GALR2 heterocomplexes. It involves especially the neuronal precursor cells of the dentate gyrus in the hippocampus for the novel treatment of Alzheimer’s disease or depression. https://hdl.handle.net/10630/25084 Neuropéptidos - Congresos Neurobiología del desarrollo - Congresos Memoria - Trastornos - Congresos Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory