2026-06-06T05:02:55Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/256532026-02-03T11:46:10Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Burgos-Molina, Antonio Manuel
author
Peinado-Ruiz, Isabel C.
author
González Vidal, Alejandro
author
Ruiz-Gómez, Miguel José
2022-12-21T07:50:45Z
2022-12-21T07:50:45Z
2022
https://hdl.handle.net/10630/25653
All tumour studied show an increase in resistance to treatment and an increase in cell survival. This response is related to an increase in the heat shock protein HSP90, since it participates in the assembly of telomerase, causing telomeres not to be shortened and leading to a longer cell life. When an HSP90 inhibitor is administered together with the usual treatment of this type of tumours, a decrease in cell survival and resistance to the antineoplastic treatment was observed. Recent scientific and clinical data show that HSP90 inhibitors strongly affect the survival of cancer cells and their use in combination with anticancer agents makes it possible to postpone cellular resistance to chemotherapy.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Tumores - Investigación
Exposure of cancer cells to heat shock protein inhibitors induces decreased tumour survival
conference output
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URL
https://riuma.uma.es/bitstreams/f3018886-41a2-4b8b-b379-514860df30fb/download
File
MD5
cdd295fe205dd18d5a55db78793d5f6b
697882
application/pdf
4- Burgos-Molina AM - Protein inhibitors.pdf