2026-05-28T17:43:43Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/256532026-02-03T11:46:10Zcom_10630_2254col_10630_37959

Exposure of cancer cells to heat shock protein inhibitors induces decreased tumour survival Burgos-Molina, Antonio Manuel Peinado-Ruiz, Isabel C. González Vidal, Alejandro Ruiz-Gómez, Miguel José Tumores - Investigación All tumour studied show an increase in resistance to treatment and an increase in cell survival. This response is related to an increase in the heat shock protein HSP90, since it participates in the assembly of telomerase, causing telomeres not to be shortened and leading to a longer cell life. When an HSP90 inhibitor is administered together with the usual treatment of this type of tumours, a decrease in cell survival and resistance to the antineoplastic treatment was observed. Recent scientific and clinical data show that HSP90 inhibitors strongly affect the survival of cancer cells and their use in combination with anticancer agents makes it possible to postpone cellular resistance to chemotherapy. 2022-12-21T07:50:45Z 2022-12-21T07:50:45Z 2022-12-21T07:50:45Z 2022 conference output https://hdl.handle.net/10630/25653 eng 18th ASEICA INTERNATIONAL CONGRESS Santiago de Compostela, España. 16 al 18 de Noviembre 2022 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional