2026-05-29T22:25:53Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/257492026-02-03T12:26:44Zcom_10630_2254col_10630_37959

The immunomodulator dimethyl taconite inhibits several key steps of angiogenesis in cultured endothelial cells Vidal-Valenzuela, Isabel Fernández-Florido, Elena Marrero Capitán, Ana Dácil Castilla, Laura Rodríguez-Quesada, Ana María Martínez-Póveda, Beatriz Amparo Medina-Torres, Miguel Ángel Angiogénesis Dimethyl itaconate (DMI) is a cell-permeable derivative of itaconate, a known immunomodulator metabolite synthesized from the Krebs cycle intermediate cis-aconitate by the enzyme aconitate dehydrogenase. Although DMI is not metabolized into itaconate intracellularly, immunomodulatory, anti-inflammatory and anti-oxidative effects has been described for this compound. Some of these processes affected by DMI are directly related to angiogenesis; however, nothing has been published yet in this field. The aim of this work is to evaluate the potential effect of DMI in different key steps of the angiogenic process. 2023-01-17T08:42:10Z 2023-01-17T08:42:10Z 2022 conference output https://hdl.handle.net/10630/25749 eng III Congreso Nacional de Estudiantes de Biociencias Cáceres 22 a 24 de octubre de 2022 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional