2026-05-30T19:01:13Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/260392026-02-03T10:51:44Zcom_10630_2254col_10630_37953

García-García, Cristina Vegas-Aguilar, Isabel María Rioja-Vázquez, Rosalía Cornejo Pareja, Isabel María Tinahones-Madueño, Francisco José García-Almeida, José Manuel 2023-02-22T13:34:07Z 2023-02-22T13:34:07Z 2023-01-19 García-García C, Vegas-Aguilar IM, Rioja-Vázquez R, Cornejo-Pareja I, Tinahones FJ, García-Almeida JM. Rectus Femoris Muscle and Phase Angle as Prognostic Factor for 12-Month Mortality in a Longitudinal Cohort of Patients with Cancer (AnyVida Trial). Nutrients. 2023; 15(3):522. https://doi.org/10.3390/nu15030522 https://hdl.handle.net/10630/26039 https://doi.org/10.3390/nu15030522 Background: Cancer-related malnutrition is still unrecognized and undertreated in clinical practice. The morphofunctional assessment of disease-related malnutrition (DRM) is a new approach that focuses on evaluating changes in body composition and function. The aim of this study is to evaluate the prognostic value of classic and emerging assessment of malnutrition at 12-months survival in cancer patients. Methods. We conducted a prospective study on cancer outpatients. Bioelectrical impedance with phase angle (PhA), nutritional ultrasound by rectus femoris cross-sectional area (RFCSA), hand grip strength, and “Timed Up and Go Test” (TUG) were evaluated as predictors of mortality. Results. Fifty-seven patients were included. The non-survivors had lower PhA values than the survivors (4.7° vs. 5.4°; p < 0.001), and we had the same results with RFCSA 2.98 cm2/m2 vs. 4.27 cm2/m2 (p = 0.03). Cut-off points were identified using the ROC (receiver operating characteristic) curves for PhA (≤5.6° cancer patients, ≤5.9° men, ≤5.3° women), RFCSA (≤4.47 cm2/m2 cancer patients, ≤4.47° men, ≤2.73° women) and rectus femoris-Y-axis (RF-Y-axis; ≤1.3 cm cancer patients, ≤1.06 men, ≤1 women). In multivariate logistic regression analysis, we found that high PhA was significantly associated with a lower mortality hazard ratio (HR: 0.42 95% CI: 0.21–0.84, p = 0.014). Likewise, high RFCSA was associated with a decrease in mortality risk in the crude model (HR: 0.61 95% CI: 0.39–0.96, p = 0.031). This trend was also maintained in the adjusted models by the confounding variables. Conclusions. Low PhA and RFCSA values are significant independent predictors of mortality in cancer patients. These cut-off points are clinical data that can be used for nutritional assessment and the prediction of clinical outcomes. eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Cancer Rectus Femoris Muscle and Phase Angle as Prognostic Factor for 12-Month Mortality in a Longitudinal Cohort of Patients with Cancer (AnyVida Trial) journal article