2026-05-31T08:19:59Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/263192026-02-03T11:33:58Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Álvarez-Contino, José Erik
author
Díaz-Sánchez, Estela
author
Mirchandani-Duque, Marina
author
Sánchez-Pérez, José Andrés
author
Barbancho-Fernández, Miguel Ángel
author
López-Salas, Alexander
author
García-Casares, Natalia
author
Fuxe, Kjell
author
Borroto Escuela, Dasiel Óscar
author
Narváez-Peláez, Manuel
2023-04-20T11:38:56Z
2023-04-20T11:38:56Z
2023
Alvarez‐Contino, J. E., Díaz‐Sánchez,E., Mirchandani‐Duque, M., Sánchez‐Pérez, J. A., Barbancho,M. A., López‐Salas, A., García‐Casares, N., Fuxe, K., Borroto‐Escuela, D. O., & Narváez, M. (2023). GALR2 and Y1Ragonists intranasal infusion enhanced adult ventralhippocampal neurogenesis and antidepressant‐like effectsinvolving BDNF actions.Journal of Cellular Physiology, 238,459–474.https://doi.org/10.1002/jcp.30944
https://hdl.handle.net/10630/26319
https://doi.org/10.1002/jcp.30944
Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder(MDD), with more than 300 million people diagnosed and worsened by the COVID‐19pandemic. Accumulating evidence for neuropeptideY (NPY) and galanin (GAL) interactionwas shown in various limbic system regions at molecular‐, cellular‐, and behavioral‐specific levels. The purpose of the current work was to evaluate the proliferating role ofGAL2 receptor (GALR2) and Y1R agonists interaction upon intranasal infusion in theventral hippocampus. We studied their hippocampal proliferating actions using theproliferating cell nuclear antigen (PCNA) on neuroblasts or stem cells and the expressionof the brain‐derived neurothrophic factor (BDNF). Moreover, we studied the formation ofY1R–GALR2 heteroreceptor complexes and analyzed morphological changes inhippocampal neuronal cells. Finally, the functional outcome of the NPY and GALinteraction on the ventral hippocampus was evaluated in the forced swimming test. Wedemonstrated that the intranasal infusion of GALR2 and the Y1R agonists promotesneuroblasts proliferation in the dentate gyrus of the ventral hippocampus and the induction of the neurotrophic factor BDNF. These effects were mediated by theincreased formation of Y1R–GALR2 heteroreceptor complexes, which may mediate theneurites outgrowth observed on neuronal hippocampal cells. Importantly, BDNF actionwas found necessary for the antidepressant‐like effects after GALR2 and the Y1Ragonists intranasal administration. Our data may suggest the translational development ofnew heterobivalent agonist pharmacophores acting on Y1R–GALR2 heterocomplexes inthe ventral hippocampus for the novel therapy of MDD or depressive‐affecting diseases.
eng
Atribución 4.0 Internacional
Neurobiología del desarrollo
Depresión - Tratamiento
GALR2 and Y1R agonists intranasal infusion enhanced adultventral hippocampal neurogenesis and antidepressant‐likeeffects involving BDNF actions
journal article
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GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant‐like effects involving BDNF actions Enhanced Reader.pdf