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oai:riuma.uma.es:10630/263502026-02-03T11:16:31Zcom_10630_2254col_10630_37953

Mercado-Sáenz, Silvia González-Vidal, Alejandro Burgos-Molina, Antonio Manuel López-Díaz, Beatriz Sendra-Portero, Francisco Ruiz-Gómez, Miguel José 2023-04-21T10:51:07Z 2023-04-21T10:51:07Z 2023 Mercado-Sáenz, S., González-Vidal, A., Burgos-Molina, A.M. et al. Pulsed magnetic field increases the effect of ultraviolet C radiation and thermal shock in aged yeasts. Int Microbiol (2023). https://doi.org/10.1007/s10123-023-00352-2 https://hdl.handle.net/10630/26350 https://doi.org/10.1007/s10123-023-00352-2 The study of the efects of the magnetic feld (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the existing literature and the multiple efects described to date, there are few published articles that study the combined efect of MF with other physical agents during the cellular aging process. In this sense, the aim of this work is to study whether low frequency and intensity pulsed and sinusoidal MF exposure produce alterations in the cell killing efect of ultraviolet C (UVC) radiation and thermal shock during the chronological aging of S. cerevisiae. Yeast cells were exposed to 2.45 mT (50 Hz) sinusoidal MF and 1.5 mT (25 Hz) pulsed MF, during 40 days of aging, in combination with UVC radiation (50 J/m2 ) and/or thermal shock (52°C). Cell survival was evaluated by clonogenic assay. The exposure of yeast to pulsed MF produces an acceleration of aging, which is not observed in cells exposed to sinusoidal MF. The pulsed MF modifes the cellular response to damaging agents only in aged S. cerevisiae cells. In this sense, the pulsed MF applied increases the damage induced by UVC radiation and by thermal shock. In contrast, the sinusoidal MF used has no efect. eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Magnetismo terrestre Células-Envejecimiento Levaduras-Fisiología Pulsed magnetic feld increases the efect of ultraviolet C radiation and thermal shock in aged yeasts journal article