2026-05-30T15:48:29Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/263692026-02-03T10:51:10Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Berthier-Torres, Marcelo Luis author Edelkraut, Lisa author López-González, Francisco Javier author López-Barroso, Diana author Mohr, Bettina author Pulvermüller, Friedemann author Starkstein, Sergio E. author Jorge, Ricardo E. author Torres-Prioris, María José author Dávila-Arias, María Guadalupe author 2022-12-07 This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone and combined with intensive language action therapy (ILAT) for the treatment of apathy and depression in ten people with chronic post-stroke aphasia. Outcome measures were the Western Aphasia Battery and the Stroke Aphasia Depression Questionnaire-21. Structural magnetic resonance imaging and 18fluorodeoxyglucose positron emission tomography were acquired at baseline and after two endpoints (Donepezil alone and Donepezil-ILAT). The intervention was found to be feasible to implement. Large treatment effects were found. Donepezil alone and combined with ILAT reduced aphasia severity, while apathy and depression only improved with Donepezil-ILAT. Structural and functional neuroimaging data did not show conclusive results but provide hints for future research. Given these overall positive findings on feasibility, language and behavioral benefits, further studies in larger sample sizes and including a placebo-control group are indicated. Berthier, M. L., Edelkraut, L., López-González, F. J., López-Barroso, D., Mohr, B., Pulvermüller, F., ... & Dávila, G. (2023). Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study. Brain and Language, 236, 105205. https://hdl.handle.net/10630/26369 https://doi.org/10.1016/j.bandl.2022.105205 Afasia Apatia Logopedia Neurobiología Neuropsicofarmacología Enfermedad cerebrovascular -- Tratamiento Enfermedad cerebrovascular -- Pacientes -- Rehabilitación Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study